ePSXe randomly freezing for a few seconds?

Hello,
My problem is exactly what's in the title. I'm playing a game, and everything is working fine, but seemingly randomly, the game freezes for about 4-5 seconds. Both audio, video, and input hang. However, after those 4-5 seconds, the game goes back to normal, and everything is fine. Audio, Video, and Input work perfectly, as if nothing ever happened. It seems to occur randomly, as I can't pinpoint any similarities between freezes.

Plugins:
Video: Pete's OpenGL2 GPU core 2.0.0
Video Settings: prntscr.com/d7a2e0
Sound: ePSXe SPU Core (Latency: 0, Sound Effects: 2)

If you need anything else let me know. Thanks! :)