Naomi stuff doesn't work in Mame yet. If you can't get it running with the Naomi emulator then its either not supported, you haven't set it up properly or there's something wrong with your CHD.
Since you haven't provided any info on what emulator you're trying to use, what you've done so far, how you've set it up, what error messages you're getting, what PC and operating system its running on or anything else, its impossible for anyone to give you any help.