Which ePSXe version you're using? I'd try 1.5.2 if you're running 1.6.0, or PSXeven if still doesn't work properly. It's also possible Pete's Direct3D works better for you, and the recommened BIOSes are SCPH-1001 and SCPH-7502, but I'm not sure this might have a big impact.
BTW you can update the Eternal SPU up to 1.50


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